国产亚洲精品aaa在线播放观看_亚洲图片 在线 日韩_中文在线观看少妇亚洲_一级毛片国产永久真人在线_688欧美人禽杂交狂配_大菠萝福建APP导航导入免费_女高中生上课自慰流白浆_乱伦国产精品欧美_日本免费极度色诱福利视频_1024视频精品手机在线观看

 


020-342?91006

020-342?91007

赫特儀器

24小時(shí)

咨詢熱線

在新生兒手術(shù)中，麻醉是否會(huì)引起神經(jīng)發(fā)育問題？
來源: | 作者:proa6c48b | 發(fā)布時(shí)間: 2018-05-11 | 5215 次瀏覽 | 分享到:
2018年4月10日

嬰兒和新生兒麻醉期間的大腦氧合

在新生兒手術(shù)中，麻醉是否會(huì)引起神經(jīng)發(fā)育問題？

在新生兒手術(shù)中，麻醉是否會(huì)引起神經(jīng)發(fā)育問題？
This has been studied for quite some time and the latest findings still leave the answer ambiguous. A multicenter study led by Vanessa Olbrecht, M.D., M.B.A aimed to shed some light on this imperative question. Though the study didn’t provide a definite answer, it did add a piece to the lasting research puzzle. Let’s take a look at what was discovered.

Potential risk factors of anesthesia during infancy include exposure to toxic substances that disrupt the function of the nervous system, or neurotoxicity, surgical disease, and injury to the brain through lack of oxygen, or cerebral hypoxia-ischemia. These are all mechanisms that can lead to neurocognitive development issues (1). Olbrecht’s study tested 453 infants less than 6 months old who were undergoing general anesthesia for thirty minutes or more. NIRS or near-infrared spectroscopy through Nonin Medical’s SenSmart X-100 system was used to measure cerebral oxygenation.

The study found that mild and moderate low cerebral saturation occurred frequently, but severe desaturation was uncommon. Additionally, low mean arterial pressure although common was not associated with low cerebral saturation.

Similar, but not directly related to Olbrecht’s research, George M. Hoffman, MD, and chief of anesthesia at the Children’s Hospital of Wisconsin and Medical College of Wisconsin (Milwaukee) led a study looking to elucidate weather anesthesia in infancy is linked to neurological impairment, or overall mortality. They tested the patient’s physical status prior to surgery and took this into account with their findings.

Hoffman’s team discovered a strong correlation between overall physical health and mortality following multiple prolonged procedures. This information suggests that the anesthesia coupled with the underlying physical condition of the patient, including diseases and physical status can be a foundation for developing neurological impairment (2).

As this issue remains highly controversial, it is important to use reliable devices such as the SenSmart X-100 system to track cerebral oxygenation during anesthesia. 這可能有助于降低缺氧的風(fēng)險(xiǎn)，進(jìn)而可能降低神經(jīng)損傷的發(fā)展結(jié)果


Given this information, how likely is it that unrecognized severe desaturation lasting longer than three minutes can explain subsequent neurodevelopmental issues (1)?